Pharmaceutical and Medical Texture Measurement

Let us show you a range of possibilities of how to measure the textural properties of of pharmaceutical and medical products with a texture analyser.


Measure a multitude of textures from raw ingredients to finished product.

The stability of a pharmaceutical product is paramount to the consumer's acceptance of it, as well as to its subsequent efficacy and safety. Development of new excipients and drug delivery systems can be challenging as effectiveness, and perhaps cost, benefits can be mitigated when quality control problems arise during manufacturing.

It is vital, therefore, that manufacturers scientifically assess any potential changes in the structure or character of their products throughout formulation, processing and distribution. That is where texture analysis plays a role in providing repeatable and actional test data on the effects on physical quality of active ingredients, inactive ingredients and finished products such as packaging for sterile products, tablets and tablet coatings, gels and transdermal delivery systems.

Tissue Engineering and Regenerative Medicine research, meanwhile, relies upon the mechanical function of engineered tissues as a primary endpoint for the successful regeneration of many biological tissues. This needs to be characterised and compared to initial benchmark function to determine quality control standards for the next generation of health care.

As the pharmaceutical industry innovates, so our materials analysis evolves, developing and adapting to provide new test solutions and methodologies for emerging requirements. When a test solution doesn’t exist we go ahead and develop it – the Tablet Disintegration Rig, Capsule/Loop Tensile Rig and Granule Compaction Rig are classic examples of our Community Registered Designs.

A wide range of PHARMACEUTICAL & MEDICAL PRODUCT test methods is built into Exponent Texture Analyser software and will automatically load at the click of a button. We help make your testing quicker to access and the analysis of your product properties already prepared for you.

Typical measurements include: • Powder compaction force • Granule compressibility / fracture strength • Hardness • Mechanical / tensile strength • Bilayer separation force • Disintegration rates • Swelling behaviour • Burst strength • Peeling characteristics • Extrudability • Gel strength • Mucoadhesion

No one knows more about the texture analysis of pharmaceutical and medical products – but don’t just take our word for it, read an example of what our customers have to say.


Testing Controlled Release Products...


Any of the texture analyser range can be used for the product tests listed. 

A selection of special attachments and typical measurements which are commonly used in this application area are shown, although this does not necessarily include the complete range available for the testing of pharmaceutical and medical products. Test procedures include: compression, puncture / penetration, tension, fracture / bending, extrusion, cutting / shearing.


Diametral tablet strength test

Tablet Strength

This diametral crush test identifies important differences in tablet characteristics missed by conventional tablet strength testers, which only measure the point force at which the tablet breaks.
Read more...

YouTube

Tablet Coating Adhesion

Tablet Coating Adhesion

This test provides a quantitative measure of the adhesion strength of the coating to the tablet surface. Such a test is useful for studying the consequences of changes in tablet coating formulation variables.
Read more...

YouTube

Gel bloom strength test

Gels

Typical measurements include gel strength, bloom strength (according to ISO standard), rupture force, adhesiveness, gel forming points and elasticity/brittleness.
Read more...

YouTube


Mucoadhesion Rig

Mucoadhesion Test Rig

Tests of solid dosage forms, semi- solids such as ointments and gels and even systems which solidify on contact with the target organ can be performed.
Read more...





Tablet Disintegration Rig

Tablet Disintegration Rig

This rig facilitates reliable assessment of the mechanical properties of fast-melt tablets. It closely replicates the in vivo conditions of the human mouth, enabling manufacturers to examine water absorption and the disintegration of associated particles.
Read more...


Testing Controlled Release Products


• Oral delivery

Tablet Indentation Hardness test

Tablet Hardness

Indentation hardness utilises a spherical probe to apply a specified load to characterise tabletting performance of individual components and mixtures.
Read more...

Tablet Strength tests

Tablet Strength

Mechanical strength is an important determinant of tablet drug release; diametral compression provides objective failure behaviour used to monitor and control the degree of compaction.
Read more...

YouTube

Mini 3 Point Bend Rig

Mini Three Point Bend Rig

Allows measurement of mechanical / tensile strength of small diameter tablets, indicating ability to withstand the rigours of handling, transportation, dispensing and usage.
Read more...

YouTube

Tablet Swelling Test

Tablet Swelling

Allows determination of dimensional changes associated with matrix hydration and swelling by using small cylinder penetration.
Read more...

Pellet Swelling test

Pellet Swelling

Progressive swelling behaviour of pellets can be accurately quantified during a defined period of liquid absorption.
Read more...


Tablet Coating Adhesion test

Tablet Coating Adhesion

Provides a quantitative measure of the adhesion strength of the coating to the tablet surface which is useful for studying the consequences of tablet coating formulation change.
Read more...

YouTube

Film Tensile Strength test

Tensile Grips

Allow the investigation of tensile properties of candidate films and thus the clinical performance of the final drug delivery device formulation.
Read more...



• Transdermal / Dermal delivery

Adhesive test on 90° Peel Rig

90° Peel Rig

Peel strength of films or patch formulations can be investigated using porcine or synthetic skin secured to the sliding platform of a 90 degree peel rig.
Read more...

YouTube

Flexible Substrate Clamp

Flexible Substrate Clamp

Offers easier sample mounting and skin securing for the measurement of the adhesion of a flexible substrate material when withdrawn from a sample.
Read more...

Adhesive bandage test on 180° Peel Rig

180° Peel Rig

For determination of the comparative 180° peeling or stripping characteristics which are essential for the application of adhesive bandages, dressings or patches.
Read more...

YouTube

Spherical Probe Adhesion test

Spherical Probe Adhesion test

A 1" spherical probe is often used to assess adhesive characteristics such as 'tack', adhesive cohesion and work of adhesion of transdermal patches and wound dressings.
Read more...

Adhesion test using a Peltier Plate

Peltier Plate

Adhesive testing performed at constant temperature (e.g. 35°C for skin controlled by a Peltier Plate attached to a texture analyser) provides a more accurate measurement.
Read more...


Back Extrusion Rig

Back Extrusion Rig

Assesses the consistency or extrudability of such products as gels, creams and lotions which affects removal from containers and product application.
Read more...



• Parenteral delivery

Gel Bloom test

Gel properties

Typical measurements include gel strength, Bloom strength (according to ISO standard), rupture force, adhesiveness, gel forming points and elasticity/brittleness.
Read more...

YouTube

Stent compression test

Stent Compression

A cylinder probe compression test provides a measure of mechanical strength, rupture force and elasticity of coronary stents.
Read more...


Adhesion test using a Peltier Plate

Peltier Plate

Adhesive testing performed at constant temperature (e.g. 35°C for skin controlled by a Peltier Plate attached to a texture analyser) provides a more accurate measurement.
Read more...


Back Extrusion Rig

Back Extrusion Rig

Assesses the consistency or extrudability of such products as gels, creams and lotions which affects removal from containers and product application.
Read more...



• Pulmonary delivery

• Mucosal delivery

• Rectal delivery

Inhaler Support Rig

Inhaler Support Rig

Enables the performance of the metering valve to be assessed using a hemispherical probe which best mimics the action of the finger for drug delivery.
Read more...

YouTube

Mucoadhesion Test Rig

Mucoadhesion Rig

Mucoadhesion measurement of solid dosage forms, semi-solids and even systems which solidify on contact with the target organ can be performed.
Read more...

Needle Probe Suppository Penetration test

Suppository Penetration

Enables suppositories to be accurately evaluated to compare differences in ingredients, processing conditions and behaviour under different temperature conditions.
Read more...

YouTube


• Vaginal delivery

• Ocular delivery


Pharmaceutical articles
Request an article about Pharmaceutical Gel applications
Request an article about Pharmaceutical Film applications
Request an article about Parenteral Delivery of drugs
Request an article about Novel Oral Dosage Forms
Request an article about Texture Analysis in Regenerative Medicine
Request an article about Pharmaceutical Texture Analysis
See patents and other references to Pharmaceutical and Medical Product Texture Analysis
See patents for Controlled Release Product Texture Analysis
Read our Blog posts about Pharmaceutical and Medical Product Texture Analysis

Back to top